2024-25 NFL Week 6 Preview - San Francisco vs. Seattle: Can the 49ers take down the Seahawks at Lumen Field? October 10, 2024 by Marc Jerbs

The Week 6 showdown between the San Francisco 49ers and Seattle Seahawks is shaping up to be an exciting contest, with both teams eager to improve their standings in the highly competitive NFC West. The game kicks off at 8:15 PM EDT at Lumen Field, a venue notorious for its passionate home crowd and tough conditions for visiting teams.

As of Week 6, the 49ers sit at 2-3, while the Seahawks hold a 3-2 record, making this a pivotal game for both teams' playoff hopes. The 49ers will face the challenge of playing on the road and dealing with the electric atmosphere created by Seahawks fans.

San Francisco 49ers vs. Seattle Seahawks Sports Bet Odds

The 49ers are the favorites to win the game. Here are our latest odds:

• The 49ers are favored by 3.5 point, with a money line of -190.
• The Seahawks are the underdogs by 3.5 point, with a money line of +165.
• The over/under is set at 49 points, with the over at -117 and the under at -103.

San Francisco will be without key offensive player like Christian McCaffrey, forcing them to lean more on running back Jordan Mason, who has stepped up in recent games. With George Kittle cleared to play, his return is a crucial piece of their passing and run-blocking game, likely pushing the 49ers toward a more balance passing and rushing attack.

On the other side, the Seahawks are also dealing with major defensive injuries, with defensive tackle Byron Murphy II, cornerback Riq Woolen, and linebacker Uchenna Nwosu all ruled out. Their absence could limit Seattle’s ability to pressure 49ers’ quarterback Brock Purdy, forcing them to rely more on depth players and adjust their defensive schemes, possibly opting for zone coverage to cover for the lack of star power.

Week 6 San Francisco 49ers vs. Seattle Seahawks Injury Report

San Francisco 49ers

PLAYER	POSITION	STATUS
Charvarius Ward	RB	Questionable
Chris Conley	WR	Questionable
Jordan Elliott	DT	Out
Demetrius Flannigan-Fowles	S	Out
Christian McCaffrey	WR	IR

Seattle Seahawks

PLAYER	POSITION	STATUS
Julian Love	S	Questionable
Boye Mafe	LB	Questionable
Derick Hall	LB	Questionable
Byron Murphy II	DT	Out
Riq Woolen	CB	Out

Both teams will need to adapt to these injury setbacks. The 49ers may emphasize a ground-and-pound running attack to exploit Seattle's weakened defense, while the Seahawks will likely focus on a strategic passing game to target the 49ers' injury-affected secondary. The outcome will depend on how well each team adjusts to these challenges while maintaining a competitive edge.

This rivalry game is crucial in the NFC West standings. A win for the 49ers could spark momentum for the rest of the season, while the Seahawks will look to build on their early success and strengthen their playoff position.

2024-25 Comparative San Francisco 49ers vs. Seattle Seahawks Stats

San Francisco 49ers 3rd NFC West (2-3) Away (0-2) | L1		Seattle Seahawks 1st NFC West (3-2) Home (2-1) | L2
25.2	Points Per Game	24.4
263.4	Passing Yards Per Game	270.8
144.0	Rushing Yards Per Game	105.4
15	Total Sacks	17
4	Total Interceptions	2